Nowadays, electromagnetic hyperthermia is considered as one of the most promising ways to upgrade effectiveness of combined forms of cancer therapy. RADMIR developers, together with scientists from the National Cancer Institute of Ukraine, have engineered a unique apparatus MAGNITHERM.
In 2013, MAGNITHERM Pilot Prototype was awarded with the State Honor Prize of Ukraine in field of Science and Technology.
The history of hyperthermia application in oncology has a long track behind, yet systematically, it has substantiated its principles of evidence-based medicine since late 20th century.
As far back as in 1999 at All- European Conference on Hyper Thermic Oncology in Rotterdam (Netherlands), results of 10 studies on effectiveness of combined hyper-thermal and chemo-therapeutical treatment of lots of tumor varieties (including breast cancer) were presented. Nowadays, the idea of radio frequency hyperthermia (RFHT) has truly won its recognized positions, being a widely used method of efficient treatment of malignant tumors.
RFHT techniques are directly applied before or after chemo-therapy or radiation therapy at treatment of resistant forms of malignant tumors. The magneto-thermia (MT) known also as inductive hyperthermia is one of trends of hyperthermia that, besides electrical, involves also the magnetic component of EM-field in radio frequency bandwidth, with purpose to localize and concentrate a targeted charge of heat upon a tumor epicenter.
Application of MAGNITHERM apparatus at short-wave-magneto-thermal procedures:
MAGNITHERM apparatus is mostly used in combination with treatments by chemo- or radio-therapy methods.
The apparatus is intended for treatment of inflammatory, rheumatic, dystrophic and tumor diseases of human body parts.
The therapeutic effect is achieved by treating a patient's tissues with the magnetic component of the shortwave electromagnetic field, causing thermal and electrochemical effects.
In terms of nominal output power, the apparatus is manufactured in two basic modifications rated as much as 80 W and 200 W.
A loop-type applicator enables carrying out sessions according to the contact technique.
1. Working frequency: 27.12 ± 0.163 MHz;
2. Limits of output power deviation on 50 Ohm Matched Load:
3. Maximum weight of apparatus: 45 kg.
Magneto-thermal phenomen has certain advantages. Contrast to potential electric field that generates in human body linear currents (which heat up mostly skin, fat, brain and bones due to relatively high resistance of their series circuitry), the magnetic field induces eddy currents in physiological fluid around numerous insulator particles (e.g., cell membranes). Blood and blood-rich tissues are heated at maximum. Moreover, the magnetic field does not change its shape in human body, but penetrates hereinto as easily as in air.
Inflammed, swollen and tumor tissues are heated within magnetic field most of all, thus adding up to selective trouble-free remedial effects. Healthy tissues’ overheating is not possible at all, because human body regulates its temperature by accelerating blood flow to evacuate extra heat reserve. Capillaries (most of which are normally closed in quiescent state), are opening. Now on, medicines (e.g., antibiotics) injected in blood, irrigate tissues more intensively, thus becoming more effective. Therefore, the magneto-thermia is applied as a booster to the medicinal therapy.
Classically, magnetic field encompasses a current-laden conductor. Be it turned into a coil, the inner field would grow up by 3 times, whilst outside and ever further from the coil, it greatly fades away. Work zone of coil’s magnetic field is considered to be limited by 3 dB attenuation, so figuratively speaking, the field actually looks like a flattened sphere resting on the coil.
To put it more precisely, the work zone- height along the coil axis makes up 0.42 coil radius. Acting in close vicinity of the conductor is a local field, which may greatly exceed the magnetic stress in the coil center if wound of a thin wire. Using thicker conductors (up to 0.1 coil radius), we can align the local field so that magnetic stress- distribution within 0.9 scope of coil-diameter would become rather uniform. Now, such a coil acts as a magnetic electrode (i.e., magnetic emittance inductor), and all other types of magnetic emitters are just combinations of various coils.
MTT is unable to provide overall hyperthermia, because being coagulated, the blood would no longer be heated up at all. Yet, thanks to the blood mobility, almost normal tissue temperature is maintained at high values of specific absorbed power – the same as with hyperthermia in a potential electric field.
The MTT is irrelevant of tissue depth, fat overheating or body surface burning problems. MT-procedural therapy of inner organs is devised and modeled virtually in the air, whilst shape and size of a would-be magnetic field are pre-set by aid of technical means.
Thanks to its physical principles, engineering solutions, biophysical and physiological effects, feasibility of well-matched combinations with other therapeutic means, the magneto-thermia represents a brand-new method of physio-therapy. In most cases, therapeutic efficiency of magneto-thermia exceeds that of any other physio-therapy techniques.
Valerii Orel et al.